This is the last of three sequential courses on clinical management with content focusing on the physiology and pathophysiology of complex and multi-system health problems managed by family nurse practitioners in primary care settings. The graduate student is provided the opportunity to expand knowledge of acute and chronic care of individuals and families across the lifespan experiencing complex health problems in primary care. Health monitoring, management strategies, and referrals are examined. Health counseling and health education are emphasized. Health promotion, health protection, disease prevention and disease management are emphasized.